학술논문
Five gene probes carry most of the discriminatory power of the 70-gene risk model in multiple myeloma.
Document Type
Article
Author
Source
Subject
*MULTIPLE myeloma
*PROGRESSION-free survival
*DNA probes
*MEDICAL genetics
*CELL proliferation
*PATIENTS
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Language
ISSN
0887-6924
Abstract
The article discusses the use of the 70-gene classifier (GEP70) model to identify multiple myeloma patients with high risk for short progression-free and overall survival. The GEP70 model is based on the date of those enrolled in Total Therapy 2. All the genes identified in the study, such as ENO1, FABP5, and TRIP13, are involved in cell proliferation and survival in different cancers. Differences in the survival of treated patients among GEP70 low- and high-risk groups are noted.