부산대학교 도서관

To define clinical and laboratory features that identify patients with neurosyphilis. Sixty-five subjects (20.1%) had neurosyphilis. Early syphilis increased the odds of neurosyphilis in univariate but not multivariate analyses. In multivariate analyses, serum rapid plasma reagin (RPR) titer ≥1:32 increased the odds of neurosyphilis 10.85-fold in human immunodeficiency virus (HIV)­uninfected subjects and 5.98-fold in HIV-infected subjects. A peripheral blood CD4+ T cell count ≤350 cells/μL conferred 3.10-fold increased odds of neurosyphilis in HIV-infected subjects. Similar results were obtained when neurosyphilis was more stringently defined as a reactive CSF VDRL test result. Serum RPR titer helps predict the likelihood of neurosyphilis. HIV-induced immune impairment may increase the risk of neurosyphilis. [ABSTRACT FROM AUTHOR]