학술논문
Toward reproducible disease models using the Systems Biology Markup Language.
Document Type
Article
Author
Source
Subject
*SYSTEMS biology
*PRICE markup
*MARKOV processes
*DISEASE progression
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Language
ISSN
0037-5497
Abstract
Disease modelers have been modeling progression of diseases for several decades using such tools as Markov models or microsimulation. However, they need to address a serious challenge; many models they create are not reproducible. Moreover, there is no proper practice that ensures reproducible models, since modelers rely on loose guidelines that change periodically, rather than well-defined machine-readable standards. The Systems Biology Markup Language (SBML) is one such standard that allows exchange of models between different software tools. Recently, the SBML Arrays package has been developed, which extends the standard to allow handling simulation of populations. This paper demonstrates through several abstract examples how microsimulation disease models can be encoded using the SBML Arrays package, enabling reproducible disease modeling. [ABSTRACT FROM AUTHOR]