학술논문
Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.
Document Type
Article
Author
Source
Subject
*CHROMOSOME abnormalities
*LYMPHOBLASTIC leukemia
*RAS oncogenes
*MITOGEN-activated protein kinase regulation
*LYMPHOBLASTIC leukemia in children
*DIPLOIDY
*GENETICS
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Language
ISSN
1042-8194
Abstract
We analyzed mutations in four genes ( FLT3, KRAS/ NRAS and PTPN11) that might disrupt the RAS/mitogen activated protein kinase (MAPKinase) signaling pathway, to evaluate their prognostic value in children younger than 16 years old with B-cell precursor acute lymphoblastic leukemia (Bcp-ALL). The overall survival (OS) was determined with the Kaplan-Meier method. MAPKinase genes were mutated in 25.4% and 20.1% of childhood and infant Bcp-ALL, respectively. Children with hyperdiploidy were more prone to harboring a MAPKinase gene mutation (odds ratio [OR] 3.18; 95% confidence interval [CI] 1.07-9.49). The mean OS of all cases was 54.0 months. FLT3 and PTPN11 mutations had no impact on OS. K/NRAS mutations were strongly associated with MLL- AFF1 (OR 5.78; 95% CI 1.00-33.24), and conferred poorer OS ( p = 0.034) in univariate analysis. [ABSTRACT FROM AUTHOR]