학술논문
Quality of harvest and role of cell dose in unrelated bone marrow transplantation: An Italian Bone Marrow Donor Registry-Gruppo Italiano Trapianto di Midollo Osseo Study.
Document Type
Article
Author
Source
Subject
*BONE marrow transplantation
*TRANSPLANTATION of organs, tissues, etc.
*ORGAN donation
*HEMATOPOIETIC system
*IMMUNE system
*BONE marrow purging
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Language
ISSN
1024-5332
Abstract
In this study, we investigated the factors affecting cell dose harvest and the role of cell dose on outcome. We analysed data from a cohort of 703 patients who underwent unrelated bone marrow transplantation facilitated by IBMDR in GITMO centers between 2002 and 2008. The median-infused cell doses is 3.7 × 108/kg, the correlation between the nucleated cells requested from transplant centers and those harvested by collection centers was adequate. A harvested/requested cells ratio lower than 0.5 was observed only in 3% of harvests. A volume of harvested marrow higher than the median value of 1270 ml was related to a significant lower infused cell dose ( χ2: 44.4; P < 0.001). No patient- or donor-related variables significantly influenced the cell dose except for the recipient younger age ( χ2: 95.7; P < 0.001) and non-malignant diseases ( χ2: 33.8; P < 0.001). The cell dose resulted an independent predictor factor for a better outcome in patients affected by non-malignant disease ( P = 0.05) while early disease malignant patients receiving a lower cell dose showed a higher risk of relapse ( P = 0.05). [ABSTRACT FROM AUTHOR]