학술논문
Variant in PNPLA3 is associated with alcoholic liver disease.
Document Type
Article
Source
Subject
*LIVER diseases
*FATTY liver
*ENZYMES
*CIRRHOSIS of the liver
*COMPLICATIONS of alcoholism
*MESTIZOS
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Language
ISSN
1061-4036
Abstract
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 × 10−10; ancestry-adjusted OR=1.79, P=1.9 × 10−5). [ABSTRACT FROM AUTHOR]