학술논문
Prostate-specific antigen patterns in US and European populations: comparison of six diverse cohorts.
Document Type
Article
Author
Simpkin, Andrew J.; Donovan, Jenny L.; Tilling, Kate; Athene Lane, J.; Martin, Richard M.; Albertsen, Peter C.; Bill ‐ Axelson, Anna; Ballentine Carter, H.; Bosch, J. L. H Ruud; Ferrucci, Luigi; Hamdy, Freddie C.; Holmberg, Lars; Jeffrey Metter, E.; Neal, David E.; Parker, Christopher C.; Metcalfe, Chris
Source
Subject
*PROSTATE-specific antigen
*DIAGNOSIS
*PROSTATE cancer
*COHORT analysis
*PUBLIC health surveillance
*EPIDEMIOLOGY
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Language
ISSN
1464-4096
Abstract
Objective To determine whether there are differences in prostate-specific antigen ( PSA) levels at diagnosis or changes in PSA levels between US and European populations of men with and without prostate cancer ( PCa). Subjects and Methods We analysed repeated measures of PSA from six clinically and geographically diverse cohorts of men: two cohorts with PSA-detected PCa, two cohorts with clinically detected PCa and two cohorts without PCa. Using multilevel models, average PSA at diagnosis and PSA change over time were compared among study populations. Results The annual percentage PSA change of 4-5% was similar between men without cancer and men with PSA-detected cancer. PSA at diagnosis was 1.7 ng/ mL lower in a US cohort of men with PSA-detected PCa (95% confidence interval 1.3-2.0 ng/mL), compared with a UK cohort of men with PSA-detected PCa, but there was no evidence of a different rate of PSA change between these populations. Conclusion We found that PSA changes over time are similar in UK and US men diagnosed through PSA testing and even in men without PCa. Further development of PSA models to monitor men on active surveillance should be undertaken in order to take advantage of these similarities. We found no evidence that guidelines for using PSA to monitor men cannot be passed between US and European studies. [ABSTRACT FROM AUTHOR]