학술논문
Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.
Document Type
Article
Author
Source
Subject
*SALMONELLA enteritidis
*VACCINES
*BACTERIOPHAGES
*CARBOHYDRATES
*IMMUNOGLOBULINS
*ANTIGENS
*
*
*
*
*
Language
ISSN
1359-7345
Abstract
The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model. [ABSTRACT FROM AUTHOR]