학술논문
Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes.
Document Type
Article
Author
Source
Subject
*HOMEOSTASIS
*DRUG delivery systems
*BIOMARKERS
*GUT microbiome
*CELL membranes
*INFLAMMATION
*IMMUNE system
*CELLULAR signal transduction
*NANOPARTICLES
*IMMUNOTHERAPY
*
*
*
*
*
*
*
*
*
Language
ISSN
1750-9378
Abstract
The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses. Moreover, these OMVs have an immense capacity to be applied in medical research, such as OMV-based vaccines and drug delivery. This review presents a comprehensive overview of emerging knowledge about biogenesis, the role, and application of these bacterial-derived OMVs, including OMV-based vaccines, OMV adjuvants characteristics, OMV vehicles (in conjugated vaccines), cancer immunotherapy, and drug carriers and delivery systems. Moreover, we also highlight the significance of the potential role of these OMVs in diagnosis and therapy. [ABSTRACT FROM AUTHOR]