학술논문
The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas
Document Type
Article
Author
Source
Subject
*WNT protein genetics
*CELL proliferation
*T cells
*THYMUS tumors
*TUMOR suppressor genes
*PHYSIOLOGY
*
*
*
*
*
Language
ISSN
1544-9173
Abstract
Tcf1 is known to function as a transcriptional activator of Wnt-induced proliferation during T cell development in the thymus. Evidence for an additional contrasting role for Tcf1 as a T-cell specific tumor suppressor gene is now presented. [ABSTRACT FROM AUTHOR]