학술논문
Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation.
Document Type
Letter
Author
Lin, Kuailu; Baenke, Franziska; Lai, Xixi; Schneider, Martin; Helm, Dominic; Polster, Heike; Rao, Venkatesh S.; Ganig, Nicole; Wong, Fang Cheng; Seifert, Lena; Seifert, Adrian M.; Jahnke, Beatrix; Kretschmann, Nicole; Ziemssen, Tjalf; Klupp, Fee; Schmidt, Thomas; Han, Yi; Weber, Tim F.; Plodeck, Verena; Nebelung, Heiner
Source
Subject
*COLORECTAL liver metastasis
*EXTRACELLULAR vesicles
*LIQUID chromatography-mass spectrometry
*SHOTGUN sequencing
*CLINICAL prediction rules
*PROTEOMICS
*DISEASE risk factors
*
*
*
*
*
*
Language
ISSN
1476-4598
Abstract
In independent validation cohorts, the level of EVP concentration was higher in CRLM patients compared to BD patients ( I p i = 0.04; Fig. Quantification of EVPs from human serum samples A Boxplot analysis of EVP concentration in the discovery cohort. Kaplan-Meier curves of the validation cohorts indicated that the EVP signature could distinguish between the risk of recurrence and death of CRLM patients (internal: p < 0.0001 and external: I p i = 0.004 validation cohort; Fig. [Extracted from the article]