학술논문
Long-Term Shedding of Infectious Epstein-Barr Virus after Infectious Mononucleosis.
Document Type
Article
Author
Source
Subject
*DNA
*EPSTEIN-Barr virus
*GENES
*SALIVA
*BLOOD diseases
*PATIENTS
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*
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Language
ISSN
0022-1899
Abstract
Epstein-Barr virus (EBV) DNA loads in peripheral blood mono- nuclear cells (PBMCs), plasma, and saliva, as well as infec- tivity of the virus in saliva, were evaluated in 20 patients for 6 months after the onset of infectious mononucleosis (TM). All patients displayed sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 (in spite of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly disappeared from plasma. These data show that patients with TM remain highly infectious during convalescence. [ABSTRACT FROM AUTHOR]