학술논문
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.
Document Type
Journal Article
Author
Benschop, Kimberley S. M.; Broberg, Eeva K.; Hodcroft, Emma; Schmitz, Dennis; Albert, Jan; Baicus, Anda; Bailly, Jean-Luc; Baldvinsdottir, Gudrun; Berginc, Natasa; Blomqvist, Soile; Böttcher, Sindy; Brytting, Mia; Bujaki, Erika; Cabrerizo, Maria; Celma, Cristina; Cinek, Ondrej; Claas, Eric C. J.; Cremer, Jeroen; Dean, Jonathan; Dembinski, Jennifer L.
Source
Subject
*MOLECULAR epidemiology
*ENTEROVIRUS diseases
*EPIDEMIOLOGY
*ECHO viruses
*RESEARCH
*SEQUENCE analysis
*BIOLOGICAL evolution
*ECHO virus diseases
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*GENOTYPES
*RESEARCH funding
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Language
ISSN
1080-6040
Abstract
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections. [ABSTRACT FROM AUTHOR]