학술논문
Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds.
Document Type
Article
Author
Source
Subject
*PRIMORDIA (Botany)
*CELLULAR signal transduction
*PROTEINS
*LABORATORY mice
*PROGENITOR cells
*STEM cells
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Language
ISSN
0950-1991
Abstract
The article presents information regarding a study to evaluate the requirement of Smad4 protein for inducing digit ray primordia in order to initiate aggregation and differentiation of chondrogenic progenitors in mouse limb buds. It mentions that the Smad4 is a mediator of canonical signal transduction. It mentions that the Smad4 is required for initiating Sox9-positive digit ray primordia formation.