학술논문
Co-occurrence of BCR-ABL1 rearrangement and CALR mutation in a single leukemic stem cell: evidence that BCR-ABL1 oncogenic addiction prevails over CALR signaling.
Document Type
Letter
Author
Source
Subject
*STEM cells
*PRELEUKEMIA
*BLOOD cell count
*CHRONIC myeloid leukemia
*LEUCOCYTES
*BLOOD cells
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Language
ISSN
1042-8194
Abstract
Chronic myeloid leukemia (CML) is characterized by the specific cytogenetic translocation t(9;22)(q34;q11), generating the Philadelphia (Ph) chromosome and its molecular counterpart I BCR-ABL1 i . Two types of I CALR i mutations have been described: a 52-bp deletion (type 1 mutation) and a 5-bp insertion (type 2 mutation) which are found in more than 80% of all I CALR i -mutant patients [[2]]. Indeed, the patient had a molecular response under IM therapy with regard to I BCR-ABL1 i expression clone but thrombocytosis appeared, suggesting the autonomous activity of the I CALR+ i clone. [Extracted from the article]