학술논문
Parkinson's disease genome‐wide association study‐linked PARK16 variant is associated with a lower risk of cognitive impairment: A 4‐year observational study.
Document Type
Article
Author
Source
Subject
*PARKINSON'S disease
*GENOME-wide association studies
*COGNITION disorders
*SCIENTIFIC observation
*COGNITIVE ability
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Language
ISSN
1351-5101
Abstract
Background and purpose: A genome‐wide association study‐linked variant (PARK16 rs6679073) modulates the risk of Parkinson's disease (PD). We postulate that there may be differences in clinical characteristics between PARK16 rs6679073 carriers and noncarriers. In a prospective study, we investigate the clinical characteristics between PARK16 rs6679073 A allele carriers and noncarriers over 4 years. Methods: A total of 204 PD patients, comprising 158 PARK16 rs6679073 A allele carriers and 46 noncarriers, were recruited. All patients underwent motor and nonmotor symptom and cognitive assessments yearly over 4 years. Results: PARK16 rs6679073 carriers were less likely to have mild cognitive impairment (MCI) compared to noncarriers at both baseline (48.1% vs. 67.4%, p = 0.027) and 4‐year follow‐up (29.3% vs. 58.6%, p = 0.007). Conclusions: PD PARK16 rs6679073 carriers had significantly lower frequency of MCI in a 4‐year follow‐up study, suggesting that the variant may have a neuroprotective effect on cognitive functions. [ABSTRACT FROM AUTHOR]