학술논문
eNAMPT actions through nucleus accumbens NAD+ /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress.
Document Type
Article
Author
Source
Subject
*CALCIUM-dependent potassium channels
*PUBERTY
*ADIPOKINES
*NUCLEUS accumbens
*WEIGHT loss
*SOCIABILITY
*OBESITY
*ANIMAL tracks
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Language
ISSN
2375-2548
Abstract
The article offers information on the reduced levels of the adipokine nicotinamide phosphoribosyltransferase (NAMPT) in fat and its extracellular form eNAMPT in blood contribute to lifelong reductions in sociability induced by peripubertal stress. It discusses that by using a series of adipose tissue and brain region–specific loss- and gain-of-function approaches, we implicate impaired nicotinamide adenine dinucleotide (NAD+)/SIRT1 pathway in the nucleus accumbens.