학술논문
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly.
Document Type
Article
Author
Shue, Francis; White, Launia J.; Hendrix, Rachel D.; Ulrich, Jason; Henson, Rachel L.; Knight, William; Martens, Yuka A.; Ni Wang; Roy, Bhaskar; Starling, Skylar C.; Yingxue Ren; Chengjie Xiong; Asmann, Yan W.; Syrjanen, Jeremy A.; Vassilaki, Maria; Mielke, Michelle M.; Timsina, Jigyasha; Yun Ju Sung; Cruchaga, Carlos; Holtzman, David M.
Source
Subject
*ALZHEIMER'S disease
*CEREBROSPINAL fluid examination
*CEREBROSPINAL fluid
*COGNITION disorders
*TAU proteins
*OLDER people
*BIOMARKERS
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Language
ISSN
2375-2548
Abstract
The immune system substantially influences age-related cognitive decline and Alzheimer's disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic Study of Aging cohort, we examined how risk factors like APOE genotype, age, and sex affect inflammatory molecules and AD biomarkers in cerebrospinal fluid (CSF). Among cognitively unimpaired individuals over 65 (N = 298), we measured 365 CSF inflammatory molecules, finding age, sex, and diabetes status predominantly influencing their levels. We observed age-related correlations with AD biomarkers such as total tau, phosphorylated tau-181, neurofilament light chain (NfL), and YKL40. APOE4 was associated with lower Aβ42 and higher SNAP25 in CSF. We explored baseline variables predicting cognitive decline risk, finding age, CSF Aβ42, NfL, and REG4 to be independently correlated. Subjects with older age, lower Aβ42, higher NfL, and higher REG4 at baseline had increased cognitive impairment risk during follow-up. This suggests that assessing CSF inflammatory molecules and AD biomarkers could predict cognitive impairment risk in the elderly. [ABSTRACT FROM AUTHOR]