학술논문
Stereoselective Approaches for Building the C14‐C21 Fragment of Eribulin.
Document Type
Article
Author
Source
Subject
*ERIBULIN
*BREAST cancer
*
Language
ISSN
2365-6549
Abstract
Herein, we report a practical stereoselective synthesis of C14‐C21 and C15‐C21 tetrahydrofuran‐based fragment of eribulin using two different approaches. The approach utilizes iodoetherification and intra molecular oxa‐Michael additions as key steps in individual approaches using R,R‐tartaric acid and L‐ascorbic acids as cost effective chiral starting materials. [ABSTRACT FROM AUTHOR]