부산대학교 도서관

In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti- HLA alloantibodies of the Ig A isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third ( n = 237, 31%) had Ig A alloantibodies. Mostly, these antibodies were found in sera that also harboured Ig G alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, Ig A anti- HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the Ig G isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the Ig A alloantibodies could be established for over half of the 237 patients with Ig A alloantibodies ( n = 124, 52%). A further 58 patients had specificities against HLA- C or HLA- DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that Ig A alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific. [ABSTRACT FROM AUTHOR]