학술논문
Protein kinase C-dependent α-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B.
Document Type
Article
Author
Source
Subject
*AMYLOID beta-protein precursor
*PROTEIN kinase C
*MYOSIN
*PHOSPHORYLATION
*CYTOSKELETON
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*
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Language
ISSN
0892-6638
Abstract
A substantial body of evidence indicates that protein kinase C (PKC) is involved in the α-secretory processing of the amyloid precursor protein (APP), an event that reduces the formation of the pathogenic amyloid-β peptide. Recently, we have shown that trafficking and processing of APP are both impaired by knockdown of myosin II-B, one of the major neuronal motor proteins. Here, we provide evidence that the α-secretory processing of APP is mediated by PKC-dependent phosphorylation of myosin II-B. This signaling pathway provides an important link between APP and the neuronal cytoskeleton and might be crucial for the understanding of the biological and pathological roles of APP. [ABSTRACT FROM AUTHOR]