학술논문
Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.
Document Type
Article
Author
Popping, Stephanie; Verwijs, Rosanne; Cuypers, Lize; Claassen, Mark A; Berk, Guido E van den; Weggheleire, Anja De; Arends, Joop E; Boerekamps, Anne; Molenkamp, Richard; Koopmans, Marion P; Verbon, Annelies; Boucher, Charles A B; Rijnders, Bart J; Vijver, David A M C van de; Investigators, for the Dutch Acute HCV in HIV Study
Source
Subject
*ANTIVIRAL agents
*DRUG resistance in microorganisms
*HEPATITIS C
*HEPATITIS viruses
*PHYLOGENY
*MEN who have sex with men
*SEQUENCE analysis
*GENOTYPES
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Language
ISSN
1058-4838
Abstract
The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS. [ABSTRACT FROM AUTHOR]