학술논문
Leishmania survival in the macrophage: where the ends justify the means.
Document Type
Article
Source
Subject
*LEISHMANIA
*MACROPHAGES
*PHAGOCYTOSIS
*HOMEOSTASIS
*METALLOPROTEINASES
IMMUNE system physiology
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*
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Language
ISSN
1369-5274
Abstract
Macrophages are cells of the immune system that mediate processes ranging from phagocytosis to tissue homeostasis. Leishmania has evolved ingenious ways to adapt to life in the macrophage. The GP63 metalloprotease, which disables key microbicidal pathways, has recently been found to disrupt processes ranging from antigen cross-presentation to nuclear pore dynamics. New studies have also revealed that Leishmania sabotages key metabolic and signaling pathways to fuel parasite growth. Leishmania has also been found to induce DNA methylation to turn off genes controlling microbicidal pathways. These novel findings highlight the multipronged attack employed by Leishmania to subvert macrophage function. [ABSTRACT FROM AUTHOR]