학술논문
A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma.
Document Type
Article
Author
Hai-Feng Zhang; Delaidelli, Alberto; Javed, Sumreen; Turgu, Busra; Morrison, Taylor; Hughes, Christopher S.; Xiaqiu Yang; Pachva, Manideep; Lizardo, Michael M.; Singh, Gurdeep; Hoffmann, Jennifer; Yue Zhou Huang; Patel, Khushbu; Shraim, Rawan; Kung, Sonia H. Y.; Morin, Gregg B.; Aparicio, Samuel; Martinez, Daniel; Maris, John M.; Bosse, Kristopher R.
Source
Subject
*ANDROGEN receptors
*GENETIC regulation
*MACROPHAGE migration inhibitory factor
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Language
ISSN
2375-2548
Abstract
The article focuses on understanding the role of the GREB1 gene in MYCN-amplified neuroblastoma (NB), a high-risk pediatric cancer. It is reported that GREB1 is found to promote cell survival independently of MYCN and is highly expressed in MYCN-amplified NB. It also identifies MYO1B as a key gene in NB, influencing invasion and metastasis.