학술논문
A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer.
Document Type
Article
Author
Source
Subject
*COLORECTAL cancer
*CARCINOEMBRYONIC antigen
*IMMUNOTHERAPY
*MICRORNA
*ADJUVANT treatment of cancer
*REVERSE transcriptase polymerase chain reaction
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Language
ISSN
1476-4598
Abstract
Using genome-wide expression profiling in patients with and without response to FOLFOX-based chemotherapy, we identified a novel 10-miRNA expression panel that can robustly predict response to FOLFOX-based adjuvant chemotherapy in patients with CRC. Herein, we performed a systematic genome-wide microRNA (miRNA) expression profiling to identify and establish a novel miRNA expression signature for predicting response to FOLFOX-based adjuvant chemotherapy in CRC patients. 1 Biomarker discovery phase of candidate miRNAs for predicting response to FOLFOX-based adjuvant chemotherapy in primary tumors from CRC patients. Keywords: Colorectal cancer; MicroRNA; Predictive biomarker; Adjuvant chemotherapy; FOLFOX EN Colorectal cancer MicroRNA Predictive biomarker Adjuvant chemotherapy FOLFOX 1 6 6 01/24/23 20230120 NES 230120 Keisuke Okuno, Raju Kandimalla and Joan Maurel contributed equally to this work. [Extracted from the article]