부산대학교 도서관

This article presents information condensed mitotic chromatin that is accessible to transcription actors and chromatin structural proteins. Although a substantial amount of attention has been focused on the mechanism by which the chromosomes condense and segregate, much less is known regarding the mechanism leading to the transcription silencing during mitosis. Several possibilities could contribute to this phenotype. To examine the accessibility of DNA to transcription factors and the dynamics of chromatin structural proteins during mitotic chromatin condensation in mammalian cells, their chromosome association kinetics using photobleaching fluorescence microscopy was analyzed.