학술논문
The First Analog of Pyrimidine Nucleosides with Two Nucleobases and Two d-Ribofuranose Residues.
Document Type
Article
Source
Subject
*PYRIMIDINE nucleosides
*BASE pairs
*ACETYL group
*PENTANE
*CLICK chemistry
*
*
*
*
Language
ISSN
1070-4280
Abstract
The reaction of 1,5-bis[1-(prop-2-yn-1-yl)uracil-3-yl]pentane with 2',3',5'-tri-O-acetyl-β-d-ribofuranosylazide followed by removing of acetyl protective groups with a solution of sodium methylate in methanol afforded 1,5-bis{[1-methyl(β-d-ribofuranosyl)-1H-1,2,3-triazole-4-yl]uracil-3-yl}pentane which is the first analog of pyrimidine nucleosides with two nucleobases and two d-ribofuranose residues. [ABSTRACT FROM AUTHOR]