학술논문
Failure of Highly Active Antiretroviral Therapy in Reconstituting Immune Response to Clostridium tetani Vaccine in Aged AIDS Patients.
Document Type
Article
Author
Source
Subject
*HIGHLY active antiretroviral therapy
*IMMUNE response
*AIDS
*TETANUS vaccines
*ANTIRETROVIRAL agents
*SERUM
*PHYSIOLOGY
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Language
ISSN
1525-4135
Abstract
The article presents a study on the effect of age on tetanus-specific immune reaction in highly active antiretroviral therapy (HAART)-treated AIDS patients by via healthy age-matched individuals. The study tested 20 HIV-1-infected individuals more than 55 years old and 20 young HIV-1-infected patients. Results showed that vitro TT-specific lymphoproliferation and serum antibody concentrations were lower in older patients and the therapy makes them capable to tetanus even after vaccination.