학술논문
Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study.
Document Type
Article
Author
Sher, Gulab; Salman, Nadia Aziz; Kulinski, Michal; Fadel, Rayyan Abdulaziz; Gupta, Vinod Kumar; Anand, Ambika; Gehani, Salahddin; Abayazeed, Sheraz; Al-Yahri, Omer; Shahid, Fakhar; Alshaibani, Salman; Hassan, Sara; Chawdhery, M. Zafar; Davies, Giles; Dermime, Said; Uddin, Shahab; Ashrafi, G. Hossein; Junejo, Kulsoom
Source
Subject
*BREAST tumor risk factors
*DNA analysis
*BREAST tumors
*LONGITUDINAL method
*PAPILLOMAVIRUS diseases
*POLYMERASE chain reaction
*DISEASE progression
*GENOTYPES
*DISEASE complications
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Language
ISSN
2072-6694
Abstract
Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types' DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer. [ABSTRACT FROM AUTHOR]