학술논문
Endothelin-1 release from atherosclerotic plaque after percutaneous transluminal coronary angioplasty in stable angina pectoris and single-vessel coronary artery disease.
Document Type
Journal Article
Author
Source
Subject
*ENDOTHELINS
*TRANSLUMINAL angioplasty
*HEART diseases
*CORONARY heart disease treatment
*ANGINA pectoris
*CORONARY disease
*MYOCARDIAL revascularization
*REFERENCE values
*SURGICAL stents
ANGINA pectoris treatment
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Language
ISSN
0002-9149
Abstract
To assess the effects of percutaneous transluminal coronary angioplasty on endothelin-1 (ET-1) release, we assessed ET-1 concentrations at different sites of the coronary circulation in patients submitted to elective procedures. ET-1 levels immediately downstream from the plaque and ET-1 aortocoronary gradient increased significantly after the procedure, which was related to mechanical wall stress in patients only receiving balloons, but not in those undergoing stent percutaneous transluminal coronary angioplasty. No changes were found in the coronary sinus; these results suggest ET-1 release from the plaque rather than an ischemia/reperfusion-related production from the distal myocardium. [ABSTRACT FROM AUTHOR]