학술논문
Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.
Document Type
Article
Author
Sabino, Janine S.; Amorim, Mariene R.; de Souza, William M.; Marega, Lia F.; Mofatto, Luciana S.; Toledo-Teixeira, Daniel A.; Forato, Julia; Stabeli, Rodrigo G.; Costa, Maria Laura; Spilki, Fernando R.; Sabino, Ester C.; Faria, Nuno R.; Benites, Bruno D.; Addas-Carvalho, Marcelo; Stucchi, Raquel S. B.; Vasconcelos, Dewton M.; Weaver, Scott C.; Granja, Fabiana; Proenca-Modena, José Luiz; Vilela, Maria Marluce dos S.
Source
Subject
*BREAST milk
*SARS-CoV-2
*POST-acute COVID-19 syndrome
*VIRUS diseases
*COVID-19 treatment
*VIRAL antibodies
*IMMUNOGLOBULINS
*ORAL mucosa
*
*
*
*
*
*
*
Language
ISSN
1999-4915
Abstract
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients. [ABSTRACT FROM AUTHOR]