학술논문

Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.
Document Type
Report
Source
Pediatric Hematology & Oncology. Aug2021, Vol. 38 Issue 5, p504-509. 6p.
Subject
*ABDOMINAL aortic aneurysms
*FIBROSARCOMA
*GENE fusion
*TREATMENT effectiveness
*AORTIC aneurysms
*AORTIC rupture
Language
ISSN
0888-0018
Abstract
Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects. [ABSTRACT FROM AUTHOR]