부산대학교 도서관

Background: Although infections are a significant potential complication among patients undergoing left ventricular assist device (LVAD) implantation, standardized surgical infection prophylaxis (SIP) regimens are not well defined. At Montefiore Medical Center, a 4‐drug SIP regimen containing fluconazole, ciprofloxacin, rifampin, and vancomycin was previously utilized. In January 2020, the antimicrobial stewardship program implemented a 2‐drug SIP regimen of vancomycin and cefazolin to limit exposure to broad‐spectrum antibiotics. This study evaluated LVAD‐associated infection rates prior to and following the SIP revision. Methods: A retrospective review of patients who underwent LVAD implantation from 1/2018 to 4/2021 was performed. Infections were classified using the International Society for Heart and Lung Transplantation definitions. Infection rates at 2 weeks, 30 days, and 90 days post‐implantation in the 4‐drug SIP regimen (1/2018‐12/2019) and the 2‐drug SIP regimen (1/2020 to 4/2021) were compared. Results: A total of 71 patients were included. The number of patients with LVAD‐associated infections (including surgical site infections) was not significantly different in either SIP group at 2 weeks (9% vs. 4%, p =.64), 30 days (9% vs. 11%, p =.99), or 90 days (19% vs. 14%, p =.75). There was no statistically significant difference in 30 or 90‐day mortality. LVAD‐associated gram‐negative (7% vs. 7%; p >.99) and fungal (5% vs. 0%; p =.51) infections were uncommon. The most common organism isolated was Staphylococcus aureus, and the most common type of infection was pneumonia in both SIP groups. Conclusion: No significant difference in LVAD‐associated infections or infection‐related mortality was observed with de‐escalation of perioperative antibiotics. Additional studies with larger sample sizes are needed to endorse the findings of this study. [ABSTRACT FROM AUTHOR]