부산대학교 도서관

Cyanamides, tetrazole and their derivatives have pharmaceutically attracted much attention because of their wide range of biological activities such as antihypertensive, anti alergic, anti-asthmatic, antimicrobial, antiviral, anti-inflammatory, anti-neoplastic and anticonvulsant activities. The aryl/alkyl cyanamides and substituted tetrazole copounds were synthesized through cobalt-promoted one-pot reaction of isothiocyanates previously in our laboratory. In the present study, 11 synthesized aryl/alkyl cyanamides and substituted tetrazole compounds were tested for their antimicrobial activity using Kirby–Bauer disc diffusion method against the reference Gram-negative (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) and Gram-positive (Staphylococcus aureus ATCC 25923 and Bacillus cereus 6A1) bacterial strains. Among the tested compounds, 1-(4-chlorophenyl)-1H-tetrazol-5-amine (XI) followed by 4-amino benzonitrile (IX) and 1-(4-methylphenyl)-1H-tetrazol-5-amine (VII) were found to be efficient in inhibiting bacteria at tested concentrations with wider zones. Further modification of tetrazole moiety may help to find even more valuable biological activities. [ABSTRACT FROM AUTHOR]