학술논문
Engineering of Hetero-Functional Gold Nanorods for the invivo Molecular Targeting of Breast Cancer Cells.
Document Type
Article
Source
Subject
*NANOSTRUCTURED materials
*MOLECULAR recognition
*CANCER cells
*BREAST cancer
*TUMOR growth
*TRASTUZUMAB
*LABORATORY mice
*MEDICAL imaging systems
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Language
ISSN
1530-6984
Abstract
A novel technique is described to functionalize gold nanorods (GNRs) allowing for invivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated invitro in the presence of blood and then invivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor. [ABSTRACT FROM AUTHOR]