부산대학교 도서관

This article explores the molecular mechanisms of loop diuretics and their effects on renal calcium and magnesium transport. Loop diuretics are commonly used to treat fluid retention in patients with heart failure, kidney disease, and cirrhosis. They primarily act on the thick ascending limb of the loop of Henle by inhibiting the NKCC2 cotransporter, resulting in increased urine volume and salt wasting. Loop diuretics also affect the reabsorption of calcium and magnesium in the kidney, leading to their loss in urine. The article discusses the role of various transporters and channels involved in calcium and magnesium reabsorption in the renal tubules. It also highlights the differential effects of loop diuretics on calcium and magnesium handling in Bartter syndrome, a genetic disorder affecting renal salt and mineral transport. Additionally, the article presents new findings suggesting that furosemide, a commonly used loop diuretic, may have beneficial effects on calcium excretion in patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC). Further research is needed to explore the therapeutic potential of furosemide in these patients. [Extracted from the article]