학술논문
Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning.
Document Type
Article
Author
Source
Subject
*NALOXONE
*MICROENCAPSULATION
*CONTROLLED release preparations
*FENTANYL
*SPRAY drying
*CYCLODEXTRINS
*SODIUM alginate
*POLYCAPROLACTONE
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Language
ISSN
0007-4888
Abstract
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED fentanyl (anesthetic effect), we studied the effects of naloxone-sodium alginate complex on the dynamics of CO concentration in the expired air. It was shown that treatment with the developed microencapsulated naloxone after fentanyl injection allowed reducing the therapeutic dose of the antagonist by more than 2 times and eliminated the necessity of repeated injections. [ABSTRACT FROM AUTHOR]