학술논문
Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control.
Document Type
Article
Author
Source
Subject
*MITOGENS
*CANCER cells
*
Language
ISSN
0950-9232
Abstract
Investigates the effect of the ablation of the function of endogenous receptor associated late transducer (RALT) on mitogenic signals of an EGFR/ErbB-2 chimeric receptor. Background on the levels of control of RALT; Ways of achieving cell ablation of growth suppressors in cancer cells; Identification of signaling pathways involved in the induction of RALT expression.