학술논문
Structure–activity study of novel tricyclic benzazepine arginine vasopressin antagonists
Document Type
Article
Author
Source
Subject
*XANTHENE
*VASOPRESSIN
*
Language
ISSN
0960-894X
Abstract
Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V1a and V2. Derivatives containing pyrrolo-tricyclic amines, 13i–k, 30, and 31 also showed selectivity for the V2 receptor. [Copyright &y& Elsevier]