학술논문
Myofibroblastic Differentiation of Stromal Cells in Giant Cell Tumor of Bone: An Immunohistochemical and Ultrastructural Study.
Document Type
Article
Source
Subject
*STROMAL cells
*GIANT cell tumors
*BONE tumors
*IMMUNOHISTOCHEMISTRY
*MYOFIBROBLASTS
*MATRIX metalloproteinases
*CANCER relapse
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Language
ISSN
0191-3123
Abstract
The nature of the mononuclear stromal cells (MSCs) in giant cell tumor of bone (GCTB) has not been thoroughly investigated. The purpose of this study was to evaluate the degree and significance of myofibroblastic differentiation in 18 cases of GCTB by immunohistochemistry (IH) and/or electron microscopy (EM). All immunostained cases were found positive for smooth muscle actin (SMA) and/or muscle specific actin (MSA), most in 1-33% of the MSCs. Ultrastructurally, most MSCs were fibroblasts, and a significant number of cells displayed myofibroblastic differentiation. Myofibroblasts are an important component of MSCs in GCTB. The myofibroblastic population may be responsible in part for the production of matrix metalloproteinases (MMPs), which probably play a role in bone destruction, tumor aggression, and recurrence. [ABSTRACT FROM AUTHOR]