학술논문
Targeting CGRP pathways and aura: A peripheral site with a central effect.
Document Type
Article
Source
Subject
*MIGRAINE aura
*SPREADING cortical depression
*DRUG efficacy
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Language
ISSN
0333-1024
Abstract
Targeting CGRP-pathways has substantially expanded our options for treating individuals with migraine. Although the efficacy of these drugs on migraine aura is yet to be fully revealed, it seems from existing studies that CGRP antagonism reduces the number of migraine auras. The present perspective summarizes the evidence linking CGRP to the migraine aura and proposes a model by which targeting the CGRP-pathways and, thus, inhibition the interaction between C- and Aδ-trigeminal fibers might reverse a possible high cortical glutamate level leading to a reduced number of migraine auras. [ABSTRACT FROM AUTHOR]