학술논문
Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: a multicenter phase I/II study.
Document Type
Article
Author
Source
Subject
*AZACITIDINE
*ACUTE myeloid leukemia
*OLDER patients
*DRUG therapy
*CYTOGENETICS
*PATIENTS
*MEDICAL care
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Language
ISSN
1042-8194
Abstract
The safety and efficacy of azacitidine (5-day schedule) were assessed in a multicenter study in 40 patients (median age 72 years) with acute myeloid leukemia (AML) medically unfit for ( n == 20) or resistant to chemotherapy ( n == 20) from April to October 2008. Median marrow blasts were 42%. After a median follow-up of 13 months, response (complete remission [CR]/partial remission [PR]/hematologic improvement [HI]) was 50% and 10% in newly diagnosed and relapsed/refractory patients, respectively ( p == 0.008). Median time-to-response was 2.5 months with a median duration of 5.9 months. Median survival was not reached for responders versus 3.8 months for 15 (38%) patients with stable disease ( p < 0.045). High-risk cytogenetics was associated with inferior survival ( p == 0.05). Lower marrow blasts on day 15 of cycle 1, irrespective of pretreatment count, predicted subsequent response ( p == 0.01). Azacitidine is active and well tolerated in elderly patients with newly diagnosed AML. [ABSTRACT FROM AUTHOR]