학술논문
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Document Type
Article
Author
Al Olama, Ali Amin; Easton, Douglas F; Kolonel, Laurence N; Le Marchand, Loic; Tammela, Teuvo L J; Auvinen, Anssi; Wahlfors, Tiina; Schleutker, Johanna; Visakorpi, Tapio; Leinonen, Katri A; Xu, Jianfeng; Zheng, S Lilly; Aly, Markus; Donovan, Jenny; Travis, Ruth C; Key, Tim J; Kote-Jarai, Zsofia; Siddiq, Afshan; Canzian, Federico; Khaw, Kay-Tee
Source
Subject
*PROSTATE cancer risk factors
*CHROMOSOME abnormalities
*META-analysis
*GENEALOGY
*CARCINOGENESIS
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Language
ISSN
1061-4036
Abstract
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10−8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease. [ABSTRACT FROM AUTHOR]