부산대학교 도서관

Objective: Kisspeptin is a neuropeptide that acts mainly on gonad otropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insulin- like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between hyperprolactinemia and circulating kisspeptin and klotho levels. Methods: In this study, 33 women with hyperprolactinemia and 28 control subjects were included. Blood samples were analyzed for follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, α-klotho, kisspeptin, and neurokinin B levels. Results: There was no difference between the groups in terms of kisspeptin and α-klotho levels (P = .68 and P = .11, respectively). Follicle-stimulating hormone and estradiol were significantly lower in the hyperprolactinemia group (P = .02 and P = .03, respectively). Kisspeptin levels were positively correlated with follicle-stimulating hormone levels (r = 0.43, P = .01) and α-klotho levels (r = 0.32, P = .01). Neurokinin B was negatively correlated with both kisspeptin and α-klotho values (r = -0.42, P = .01 and r = -0.29, P = .02, respectively). Body mass index was positively correlated with kisspeptin and negatively correlated with α-klotho molecule (r = 0.273, P = .03 and r = -0.25, P = .04, respectively). Conclusion: Hyperprolactinemia does not affect circulating kisspeptin and α-klotho levels but positively correlates with kisspeptin and α-klotho, which are known to play a role in complex interactions between the hypothalamus and the pituitary that may be the subject of new studies in the future. [ABSTRACT FROM AUTHOR]