학술논문
Kinetics and mechanism of inhibition of serine esterases by fluorinated carbethoxy 1-aminophosphonates.
Document Type
Article
Author
Source
Subject
*FLUORINATION
*PHOSPHONATES
*HYDROLASES
*ORGANIC compounds
*PHOSPHORUS
*ESTERASES
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*
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Language
ISSN
1607-6729
Abstract
The article presents a study on the kinetics of interaction of fluorinated carbethoxy-1-aminophosphonates using a chemical formula with serine hydrolases which played an important role in the pharmacological and toxicological effects of organic phosphorus inhibitors (OPIs). It explores the structure of the compounds through quantum-mechanical calculations to elucidate the mechanism of inhibition of serine esterases. The relative strength of the P-C bond in the tested compounds are discussed.