학술논문
Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia.
Document Type
Journal Article
Author
Source
Subject
*CLINICAL drug trials
*OLANZAPINE
*CLINICAL medicine research
*RISPERIDONE
*COCAINE abuse treatment
*ANTIPSYCHOTIC agents
*DOPAMINE antagonists
*DRUG abuse
*SCHIZOTYPAL personality disorder
*THERAPEUTICS
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Language
ISSN
1055-0496
Abstract
A 14-week double blind study compared the efficacy of olanzapine to risperidone in reducing marijuana/cocaine craving and use in individuals with schizophrenia. The study consisted of three phases: a two-week assessment phase, a two-week cross-taper phase onto olanzapine/risperidone, and a ten-week period of maintenance on olanzapine/risperidone. The proportion of cocaine-positive urines decreases over time for both groups with a trend for a greater reduction for the olanzapine group compared to risperidone group. In the last six weeks, marijuana craving was more likely for the risperidone group compared to the olanzapine group, although there was no group difference in the proportion of negative marijuana urines. The data suggest some potential for the utility of olanzapine for the treatment of cocaine dependence in individuals with schizophrenia. [ABSTRACT FROM AUTHOR]