학술논문
Effects of sulfoxide and sulfone sidechain–backbone hydrogen bonding on local conformations in peptide models.
Document Type
Article
Source
Subject
*PEPTIDES
*HYDROGEN bonding
*AMINO acid residues
*SULFOXIDES
*SYSTEMS design
*SPINE
*FUNCTIONAL groups
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Language
ISSN
1359-7345
Abstract
We examine peptide model systems designed to probe short-range N–H⋯O＝S sidechain–backbone hydrogen bonding involving amino acid residues with sidechain sulfoxide or sulfone functional groups and its effects on local conformations. A strong 7-membered ring hydrogen bond of this type accompanies an intra-residue N–H⋯O＝C interaction and stabilizes an extended backbone conformation in preference to classical folded structures. [ABSTRACT FROM AUTHOR]