학술논문

Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder.
Document Type
Article
Source
Journal of Cellular Physiology. Mar2019, Vol. 234 Issue 3, p2067-2082. 16p.
Subject
*BIOLOGICAL tags
*OBSTRUCTIVE lung diseases
*OXIDATIVE stress
*ANTIOXIDANTS
*MORTALITY
Language
ISSN
0021-9541
Abstract
A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the world. Recent research development in COPD focuses on accelerated aging and various oxidative stress biomarkers. It involves the clinical manifestation of the disease process and may also contain biochemical, immunological, physiological, morphological, and genetic aspects that add to the progressiveness of the disease. Herein, we summarize findings that highlight the role of dimensions of COPD in the investigation of oxidative stress, inflammatory responses, genetic and epigenetic studies, and pharmacological and dietary antioxidant intervention. Chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Recent research development in COPD focuses on accelerated aging and various oxidative stress biomarkers. [ABSTRACT FROM AUTHOR]