부산대학교 도서관

Objective: The aim of our study is to detect factors related with local recurrence in patients treated for in situ breast cancer. Materials and Methods: The patients treated with the diagnosis of DCIS between 1998 and 2018 in our breast center included the study. Kaplan-Meier method and Cox regression was used for statistical analyses. Statistical analyses was performed with SPSS 22.0 Results: Median age was 49 (28-82). Median floow-up 83 (12-244). Thirtyfive patients underwent mastectomy whilst 233 breast conserving surgery. One hundered seventy six patients underwent sentinel lymph node biopsy, 9 patients axillary dissection. No axillary surgery for 53 patients. One hundered ninety three patients underwent radiation theraphy following surgery and 169 patients got hormonal theraphy. Median surgical margin width was 10 (0-25) mm. During our follow up 11 patients developed local recurrence. Three of them was DCIS, 8 were invasive cancer. Contralateral breast cancer occurred in 4 patients. Two patients were lost duo to reasons not related with breast cancer. Five years disease free survival was 97%, 10 years disease free survival was 91%. Five years local recurrence free survival was 99%, 10 years local recurrence free survival was 93%. In multivariate analyses age at diagnosis (=40 vs>40)(p=0.004, HR: 7.1; 95% CI:1.85-27.2), surgical margin width (both =2mm vs >2mm and =3mm vs >3mm)(p=0.01, HR:5.4;95% CI: 1.5-19.5, p=0.03, HR:4.1;95% CI: 1.14-15.1 respectivly) and tumor size (p=0.005, HR;1.033; 95% CI: 1.01-1.05)were significantly related with local recurrence. In multivariate analyses tumor size (p=0.029, HR: 1.033; 95% CI:1.003-1.006) and margin width (both =2mm vs >2mm and =3mm vs >3mm) (p=0.003, HR:10.24; 95% CI: 2.1-48.3, p=0.01, HR:7.6;95% CI: 1.61-35.7 respectivly) detected as significantly related with local recurrence. Conclusion: In our study tumor size and surgical margin width were detected as independent factors significantly related with local recurrence. =3mm surgical margin width was found to have an independent effect on local recurrence together with =2 mm surgical margin accepted in the current literature. [ABSTRACT FROM AUTHOR]