학술논문
Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.
Document Type
Article
Author
Iuso, Domenico; Garcia-Saez, Isabel; Couté, Yohann; Yamaryo-Botté, Yoshiki; Erba, Elisabetta Boeri; Adrait, Annie; Zeaiter, Nour; Tokarska-Schlattner, Malgorzata; Jilkova, Zuzana Macek; Boussouar, Fayçal; Barral, Sophie; Signor, Luca; Couturier, Karine; Hajmirza, Azadeh; Chuffart, Florent; Bourova-Flin, Ekaterina; Vitte, Anne-Laure; Bargier, Lisa; Puthier, Denis; Decaens, Thomas
Source
Subject
Language
ISSN
2375-2548
Abstract
The article focuses on the role of nucleoside diphosphate kinases 1 and 2 (NME1/2) in regulating fatty acid accumulation in response to a high-fat diet. Topics discussed include the unique binding mode of NME1 with acetyl–coenzyme A (AcCoA), the impact of Nme2 knockout on triglyceride synthesis and liver steatosis in high-fat diet (HFD)-fed mice, and the epigenetic regulation of a protective liver response through targeted histone acetylation by NME2.